You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://zaneooed824.lakeviewbrief.com/posts/what-san-diego-homeowners-should-do-about-roof-rats

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.